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| Rouge: Issues Facing Pharmaceutical and Biotechnology Industries |
Patrick Banes |
| Rouging of stainless steel plagues the pharmaceutical and biotech community. Some degree of rouging can be found in most high temperature, high purity water and steam systems. Companies struggle to decide a course of action to deal with the phenomena. The presence of rouge is not acceptable to some, while others are not overly concerned by its presence. Typically, there are more questions than answers when it comes to the topic of rouge. This presentation will address its origin, classification, chemical composition, mechanics of distribution within a system, varying appearance and texture, impact to the base metal, concerns of product contamination, how it can be removed and the frequency of removal. |
| Controls and Instrumentation: The Brains of a High Purity Water System |
David Ferguson |
| Control systems have evolved over the past decades from banks of relays to powerful programmable logic controllers. These developments have allowed tremendous advancements in the systems and processes under control and in the ability to record and monitor the their status. The interface to these systems has likewise developed from individual status light signals and push buttons into full graphic displays of the given processes, including detailed information on system performance and alarm conditions. Additionally, improvements in instrumentation have made control systems better able to monitor and react to any number of desired parameters in real time. This presentation will describe advancements in controls and instrumentation as related to high purity water systems and the impact this has had on the end user, with special attention given to the differences in control system features as a function of the equipment in operation. |
| Electrodeionization (EDI) |
Jeff Tate |
| Electrodeionization (EDI) has been widely used for generating continuous, ultrapure water without chemical regeneration for over 20 years. The technology has evolved over this time as efforts to improve the technology developed. EDI is now widely accepted and preferred over chemically regenerated mixed beds. Various EDI manufacturers provide the customer with options in technology, style and performance. This presentation will review all the EDI options available, design features, benefits and evaluation of performance. |
| Biofilm: Detection and Control |
T. C. Soli, Ph.D. |
| Enough has been mentioned about the presence of biofilm growing in water systems over the past decades that there is hardly an individual involved with water that is not aware that biofilm can be a problem. However, the nature of the problems biofilm causes can be very different depending on the uses of that water, which broadly correlates with its purity. This presentation will explore the biofilm differences between low and high purity waters and the impact of its presence, as well as focus on the methods used for its detection and control in high purity water systems and how and why it differs from the commonly used practices in low purity waters. |
| Selecting the Best Activated Carbon Adsorption System |
Henry Nowicki, Ph.D. |
As an activated carbon adsorption system user, you need educate yourself on the key issues. Determination if activated carbon is the treatment solution for a liquid application will be covered. Factors affecting adsorption and types of adsorption systems will be covered. The five major things to remember after the lecture are: 1) New activated carbon structure, 2) 40:40:20 Rule, 3) Water wetting of carbon, 4) Gravimetric Rapid Pore Size Distribution (GRPD), 5) Competitive adsorption and rollover and temperature effect.
We will discuss major sources of carbon and how they are manufactured briefly. Main differences between coal, coconut, and wood based activated carbons and reactivation options for used carbons will be presented.
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| The Latest in Filtration: Z.Plex Filter Technology |
William Laidlaw |
| Patented Z.Plex™ filter manufacturing technology represents years of media research and filtration technology expertise. Engineered for greater void volume than current melt blown filters, Z.Plex technology incorporates smaller diameter fibers and an innovative 3-dimensional fiber matrix that maintains structural integrity while greatly increasing filter capacity. In contrast to conventional melt blown graded density filters, which consist of 2-dimensional, layered fiber strands that create voids to trap dirt and other contaminants, the Z.Plex filter technology features a 3-dimensional fiber structure. It's the innovative addition of transverse Z-fibers that supports the increased layer spacing. The smaller diameter fibers and increased space between layers result in more void volume to offer up to 100% greater dirt holding capacity, up to 100% longer filter life, and up to 50% decreased pressure drop. |
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